Which molecule is regarded as carrier of TCA cycle ?
**Core Concept**
The tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or Krebs cycle, is a key metabolic pathway that generates energy through the oxidation of acetate derived from carbohydrates, fats, and proteins. The TCA cycle is a crucial component of cellular respiration, occurring in the mitochondria of eukaryotic cells.
**Why the Correct Answer is Right**
The molecule regarded as the carrier of the TCA cycle is **Coenzyme A (CoA)**. CoA plays a central role in the TCA cycle by facilitating the transfer of acetyl groups from pyruvate to oxaloacetate, initiating the cycle. This process involves the formation of citrate, which is then cleaved to regenerate oxaloacetate, allowing the cycle to continue. CoA is essential for the TCA cycle's function and is a critical molecule in cellular metabolism.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not relevant to the TCA cycle.
* **Option B:** NADH is a product of the TCA cycle, but it is not the carrier molecule.
* **Option C:** FADH2 is also a product of the TCA cycle, but it is not the carrier molecule.
**Clinical Pearl / High-Yield Fact**
The TCA cycle is a critical component of cellular respiration, generating approximately 90% of the ATP produced in the mitochondria. Understanding the role of CoA in the TCA cycle is essential for grasping cellular metabolism and energy production.
**Correct Answer: C. Coenzyme A (CoA).**