Which is the most common subtype of classical Hodgkin lymphoma?
Correct Answer: Nodular sclerosis type
Description: The WHO classification recognizes two major types of Hodgkin lymphoma: Classical Hodgkin lymphoma (CHL) & Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) Classical Hodgkin lymphoma is fuher classified into four subtypes: Nodular sclerosis - most common form of Hodgkin lymphoma, constituting 65% to 70% of cases. Mixed-cellularity - constitutes about 20% to 25% of cases. Lymphocyte-rich - uncommon Lymphocyte-depleted - least common, <5% cases, predominantly seen in HIV-positive patients. The Reed-Sternberg cells in Classical HL have a similar distinctive immunophenotype: Positive for CD15, CD30 and weakly positive for PAX5 (a B-cell transcription factor) Negative for other B-cell markers (CD20), CD45 (leukocyte common antigen) and T-cell markers In case of Nodular Lympocyte predominant Hodgkin lymphoma (NLPHL): RS cell variant 'Popcorn cells' are present, which are CD15 and CD30 negative and positive for CD20.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now