Which is raised in polycystic ovarian syndrome:
## **Core Concept**
Polycystic ovarian syndrome (PCOS) is a hormonal disorder common among women of reproductive age, characterized by **hyperandrogenism**, **ovulatory dysfunction**, and **polycystic ovaries**. The condition is associated with insulin resistance, which contributes to its pathophysiology.
## **Why the Correct Answer is Right**
The correct answer, **LH (Luteinizing Hormone)**, is elevated in PCOS. This elevation is a key feature of the disorder and contributes to the **hyperandrogenism** observed. The mechanism involves the **pulsatile GnRH (Gonadotropin-Releasing Hormone) secretion**, leading to an increase in LH levels compared to FSH (Follicle-Stimulating Hormone). This imbalance disrupts normal ovulation and contributes to the development of cysts on the ovaries.
## **Why Each Wrong Option is Incorrect**
- **Option A: FSH** - FSH levels are typically normal or low in PCOS, not elevated. The LH/FSH ratio is often used as a diagnostic criterion, with a high ratio suggestive of PCOS.
- **Option B: Prolactin** - While prolactin levels can be elevated in some cases of PCOS, it is not a defining characteristic of the syndrome.
- **Option C: TSH (Thyroid-Stimulating Hormone)** - TSH levels are not directly related to the primary pathophysiology of PCOS, although thyroid dysfunction can coexist with PCOS.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl for PCOS is that patients often present with **oligomenorrhea** (infrequent menstrual periods), **hirsutism** (excessive hair growth in a male-like pattern), and **acne**. The diagnosis is supported by the Rotterdam criteria, which include **oligo-anovulation**, **clinical and/or biochemical signs of hyperandrogenism**, and **polycystic ovaries on ultrasound**.
## **Correct Answer: B. LH.**