Microbiology Which is not true regarding superantigen? A Bind T cells irrespective of antigen specificity of TCR B Bind directly to both MHC II and T cell receptor causing T cell activation C Bind to cleft (antigen binding groove) in the MHC II molecule D Binds directly to lateral aspect of T cell receptor 💡 Explanation Which is not true regarding superantigen? ✓ Correct Answer: C. Bind to cleft (antigen binding groove) in the MHC II molecule