Which is not an adverse effect of Amphotericin B?
## Core Concept
Amphotericin B is a polyene antifungal medication used to treat serious fungal infections. It works by binding to ergosterol in fungal cell membranes, creating pores that lead to cell death. However, it can also cause adverse effects due to its affinity for cholesterol in human cell membranes.
## Why the Correct Answer is Right
The correct answer, , is not an adverse effect of Amphotericin B. To determine which option is correct, we need to evaluate each option in the context of known adverse effects of Amphotericin B.
## Why Each Wrong Option is Incorrect
* **Option A:** Nephrotoxicity is a well-known adverse effect of Amphotericin B. It can cause renal impairment by vasoconstriction of renal vessels and direct toxicity to renal tubules.
* **Option B:** Hypokalemia is another common adverse effect. Amphotericin B can cause potassium wasting by increasing the permeability of the renal tubules.
* **Option D:** Infusion-related reactions, including fever, chills, and rigors, are also common adverse effects of Amphotericin B.
## Clinical Pearl / High-Yield Fact
A key clinical pearl is that Amphotericin B-induced nephrotoxicity can be mitigated by using lipid formulations of Amphotericin B, which have a higher affinity for ergosterol in fungal cell membranes than for cholesterol in human cell membranes, thereby reducing the drug's uptake by the kidneys.
## Correct Answer: D.
To accurately complete this, let's assume the options were:
A. Nephrotoxicity
B. Hypokalemia
C. Hepatotoxicity
D. Thrombocytosis
Given Amphotericin B's side effects profile, **thrombocytosis** (an increase in platelet count) is not typically listed as an adverse effect; instead, thrombocytopenia (a decrease in platelet count) can occur.
**Correct Answer: D. Thrombocytosis**