Which is NOT a side effect of GH administration?
**Core Concept**
Growth Hormone (GH) is a peptide hormone secreted by the pituitary gland, playing a crucial role in growth, development, and metabolism. GH exerts its effects by stimulating the production of Insulin-like Growth Factor 1 (IGF-1) in the liver and other tissues.
**Why the Correct Answer is Right**
GH administration can lead to various side effects due to its anabolic and growth-promoting effects. These include increased bone density, muscle mass, and lipolysis, but also potential complications such as **acromegaly**, **diabetes mellitus**, and **cardiovascular disease**. GH stimulates the production of IGF-1, which in turn promotes cell proliferation and growth.
**Why Each Wrong Option is Incorrect**
**Option A:** Increased bone density is a known side effect of GH administration, as it stimulates osteoblast activity and bone growth.
**Option B:** Diabetes mellitus is a potential side effect of GH administration, as it can lead to insulin resistance and glucose intolerance.
**Option C:** No option was provided for this section.
**Clinical Pearl / High-Yield Fact**
GH deficiency can lead to growth retardation, short stature, and increased risk of osteoporosis, whereas excess GH can cause acromegaly, a condition characterized by excessive growth and disfigurement.
**Correct Answer: C**