**Question:** Which is not a feature of Edwards syndrome?

A. Hypotonia
B. Congenital heart defects
C. Short stature
D. Cataracts

**Core Concept:** Edwards syndrome is a chromosomal disorder characterized by the presence of an additional copy of chromosome 18. This leads to various clinical features.

**Why the Correct Answer is Right:** D. Cataracts is not a feature of Edwards syndrome because cataracts are due to abnormal lens development and are not directly related to the presence of an extra chromosome 18.

**Why Each Wrong Option is Incorrect:**

A. Hypotonia (low muscle tone) can be present in Edwards syndrome because the additional chromosome can affect muscle development and function.

B. Congenital heart defects are common in Edwards syndrome due to the involvement of multiple organ systems, including the cardiovascular system.

C. Short stature is also a feature of Edwards syndrome, as the additional chromosome can interfere with growth hormone production and action.

**Clinical Pearl / High-Yield Fact:**

Edwards syndrome shares some features with other chromosomal disorders, such as Down syndrome (trisomy 21), which can make differentiation challenging. However, recognizing the unique features of each condition can aid in accurate diagnosis and appropriate management.

**Correct Answer:** D. Cataracts (Option D) is not a feature of Edwards syndrome (response to Option D).