Which glut transports glucose from intestine to liver
## Core Concept
The question tests knowledge of glucose transporters (GLUTs) and their roles in glucose metabolism, particularly focusing on the transport of glucose from the intestine to the liver. GLUTs are a family of proteins that facilitate the transport of glucose across cell membranes.
## Why the Correct Answer is Right
GLUT2 is predominantly found in the liver, pancreas, and kidneys. It has a high Km for glucose, which means it is primarily involved in the transport of glucose when blood glucose levels are high. GLUT2 is known to transport glucose out of the liver into the bloodstream and also plays a role in sensing blood glucose levels. Importantly, GLUT2 is involved in the transport of glucose from the intestine into the bloodstream and then to the liver.
## Why Each Wrong Option is Incorrect
* **Option A:** GLUT1 is widely distributed in various tissues and is responsible for basal glucose uptake. It has a low Km for glucose, making it efficient at low glucose concentrations, but it is not specifically noted for transporting glucose from the intestine to the liver.
* **Option B:** GLUT3 also has a high affinity for glucose (low Km) and is primarily found in neurons and the placenta. It is crucial for the high glucose demand of neurons but not specifically for glucose transport from intestine to liver.
* **Option D:** GLUT4 is primarily found in adipose tissue and striated muscle (skeletal and cardiac muscle) and is insulin-responsive. It plays a key role in glucose metabolism postprandially but is not the primary GLUT for transporting glucose from the intestine to the liver.
## Clinical Pearl / High-Yield Fact
A key point to remember is that GLUT2 is associated with **facilitated diffusion** of glucose and is crucial in the liver for **glucose sensing** and regulation of glucose metabolism. This is particularly relevant in the context of diabetes mellitus and glucose homeostasis.
## Correct Answer Line
**Correct Answer: C. GLUT2**