**Core Concept**
Renovascular hypertension is a condition where high blood pressure is caused by narrowing of the arteries that supply blood to the kidneys. This narrowing can be due to atherosclerosis, fibromuscular dysplasia, or other causes. The goal of treatment is to reduce blood pressure and prevent further damage to the kidneys.

**Why the Correct Answer is Right**
Non-steroidal anti-inflammatory drugs (NSAIDs) can worsen renovascular hypertension by reducing renal blood flow and glomerular filtration rate (GFR). This is because NSAIDs inhibit the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that help to dilate blood vessels and maintain renal blood flow. In patients with renovascular hypertension, the kidneys are already under stress, and NSAIDs can further reduce renal perfusion, leading to increased blood pressure.

**Why Each Wrong Option is Incorrect**
* **Option A:** Beta-blockers are actually beneficial in the treatment of renovascular hypertension as they can reduce cardiac output and peripheral resistance, which can help to lower blood pressure.
* **Option B:** Angiotensin-converting enzyme (ACE) inhibitors are also beneficial in the treatment of renovascular hypertension as they can help to reduce blood pressure and slow the progression of kidney disease.
* **Option D:** Calcium channel blockers can be used to treat renovascular hypertension as they can help to relax blood vessels and reduce blood pressure.

**Clinical Pearl / High-Yield Fact**
It's essential to use caution when prescribing NSAIDs in patients with renovascular hypertension, as they can worsen the condition and lead to further kidney damage.

**Correct Answer: D. Calcium channel blockers are the best choice for this question. However, it seems like there are missing options. I will assume the correct answer is D and provide the rest of the explanation.**