Which drug is used to suppress lactation? (Repeat)
Correct Answer: Bromocriptine
Description: Ans: A (Bromocriptine) Ref: Basic & Clinical Pharmacology, Katzung 12th ed.Explanation:Dopamine agonists suppress prolactin release very effectively in patients with hyperprolactinemia.Bromocriptine and cabergoline are ergot derivatives with a high affinity for dopamine D2. receptors. Quinagoiide. a drug approved in Europe, is a non ergot agent with similarly high D: receptor affinity.ADR: Dopamine agonists can cause nausea, headache, light-headedness, orthostatic hypotension and fatigue. Psychiatric manifestations occasionally occur, even at lower doses, and may take months to resolve.Erythromelalgia occurs rarely. High dosages of ergot-derived preparations can cause cold- induced peripheral digital vasospasm. Pulmonary infiltrates have occurred with chronic high- dosage therapy.Cabergoline appears to cause nausea less often than bromocriptine. Receptor subtypesAgonistAntagonistMechanismGlutamateX-Methyl D-aspartate (NMDA)NMDA2-amino-5-phosphonovalerate DizocilpineExcitatory AMPAAMPACNQXExcitatory KainateKainic acidDomoic acid MetabotriopicACPD QuisqualateMCPGInhibitory (Presynaptic)GABAGABA -AMuscimolBicuculline PicrotoxinInhibitory GABA -BBaclofen2-hydroxy SaclofenInhibitoryDopamineD1 PhenothiazinesInhibitory D2BromocriptinePhenothiazine ButyrophenonesInhibitoryAcetylcholineMuscarinic MlMuscdrinePirenzepine AtropineExciatatory Muscarinic M2Muscarine BethanecholAtropine MethoctramineInhibitory Nicotinic. NicotineDihydro beta erythroidine Alpha- bungarotoxinExciatatory
Category:
Pharmacology
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