**Core Concept**
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and neuronal damage. The primary pathophysiology involves the accumulation of amyloid-beta plaques and tau protein tangles in the brain, leading to neuronal dysfunction and death.

**Why the Correct Answer is Right**
The management of Alzheimer's disease involves the use of cholinesterase inhibitors, such as donepezil, rivastigmine, and galantamine, which increase acetylcholine levels in the brain by inhibiting its degradation. Another class of medications used is memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, which reduces excitotoxicity caused by excessive glutamate release. These drugs aim to alleviate symptoms and slow disease progression. However, some medications are not used in Alzheimer's disease due to their potential to exacerbate cognitive decline or worsen symptoms.

**Why Each Wrong Option is Incorrect**
**Option A:** Donepezil is a cholinesterase inhibitor used in Alzheimer's disease to improve cognitive function.
**Option B:** Memantine is an NMDA receptor antagonist used to treat Alzheimer's disease by reducing excitotoxicity.
**Option C:** Rivastigmine is another cholinesterase inhibitor used in Alzheimer's disease to increase acetylcholine levels.
**Option D:** Antipsychotics, such as haloperidol, are not used as first-line treatment for Alzheimer's disease due to the risk of worsening cognitive function, increased mortality, and other adverse effects.

**Clinical Pearl / High-Yield Fact**
Antipsychotics can worsen cognitive decline and increase mortality in patients with Alzheimer's disease, making their use a classic exam trap. It's essential to recognize the potential risks and benefits of these medications in the context of Alzheimer's disease management.

**Correct Answer:** D.