**Question:** Which drug causes bull's eye macula?

**Core Concept:** Bull's eye macula is a characteristic clinical presentation associated with certain medications or diseases affecting the retina.

**Why the Correct Answer is Right:**
* The correct answer, *D*, refers to the drug *Rhupus*, which is an anagram for "Rhuematoid arthritis". Rhupus is a combination of two autoimmune diseases: *Rhumatoid* arthritis and *Sjogren's syndrome*.
* Both diseases can lead to the development of systemic lupus erythematosus, a condition characterized by inflammation and damage to various organs, including the eyes.
* Inflammatory processes in the retina can cause the characteristic bull's eye macula, which appears as a central zone of hyporeflective area surrounded by a ring of hyperreflectivity due to retinal vasculitis and inflammation.

**Why Each Wrong Option is Incorrect:**
* Option A ("A") is incorrect because Arthritis is a group of diseases characterized by joint inflammation, not retinal effects.
* Option B ("B") is incorrect as it refers to a chemical compound, "Benzodiazepines", which are a class of drugs primarily used as anxiolytics, sedatives, and hypnotics. These drugs do not cause bull's eye macula.
* Option C ("C") is incorrect as it refers to a condition, "G6PD deficiency", which is a genetic disorder affecting the enzyme glucose-6-phosphate dehydrogenase. This condition does not cause bull's eye macula.

**Clinical Pearl:**
Understanding the pathogenesis of bull's eye macula aids in diagnosing and managing the underlying autoimmune diseases (e.g., Rhupus) and other conditions causing retinal inflammation and vasculitis. A thorough history, examination, and appropriate investigations are crucial in arriving at an accurate diagnosis.

**Correct Answer:** D (Rhupus)

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In summary, the correct answer is D ("Rhupus") because it represents the combination of *Rhumatoid* arthritis and *Sjogren's syndrome*, which can lead to systemic lupus erythematosus and consequently cause bull's eye macula due to retinal inflammation and vasculitis. Always consider the potential association between systemic diseases and ocular manifestations when assessing patients with ocular symptoms.