Which drug can be given in G-6-P-D deficiency ?
**Core Concept**
In glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, red blood cells are susceptible to oxidative stress, leading to hemolysis. To manage this condition, certain medications can be used to reduce oxidative damage.
**Why the Correct Answer is Right**
Pentoxifylline is a xanthine oxidase inhibitor that can be used in G-6-PD deficiency. It works by inhibiting the enzyme xanthine oxidase, which is involved in the production of reactive oxygen species. By inhibiting this enzyme, pentoxifylline reduces oxidative stress and subsequent hemolysis in red blood cells. This makes it a suitable option for patients with G-6-PD deficiency.
**Why Each Wrong Option is Incorrect**
**Option A:** Aspirin is not typically used in G-6-PD deficiency as it can further increase oxidative stress.
**Option B:** Furosemide is a loop diuretic and does not have a direct effect on G-6-PD deficiency.
**Option C:** Phenobarbital is a barbiturate and does not have a specific role in managing G-6-PD deficiency.
**Clinical Pearl / High-Yield Fact**
Pentoxifylline is an important medication to know in the context of G-6-PD deficiency, as it can help reduce oxidative stress and prevent hemolysis. This is particularly relevant in patients who require anticoagulation or antiplatelet therapy.
**Correct Answer:** C.