Which bacteria penetrates intact cornea ?
**Core Concept**
The question is testing the knowledge of the virulence and pathogenicity of different types of bacteria, specifically their ability to penetrate intact corneal tissue. The intact cornea is a relatively impermeable barrier that normally prevents bacterial invasion.
**Why the Correct Answer is Right**
Neisseria gonorrhoeae is a highly virulent bacterium that can penetrate intact corneal tissue. This is due to its unique ability to adhere to and invade corneal cells using its pili and outer membrane proteins. Once inside the cornea, N. gonorrhoeae can cause severe inflammation and tissue damage, leading to corneal ulcers and potentially permanent vision loss.
**Why Each Wrong Option is Incorrect**
**Option A:** Staphylococcus aureus is a common cause of ocular infections, but it typically requires a breach in the corneal epithelium to invade the cornea. It is not typically associated with penetration of intact corneal tissue.
**Option B:** Pseudomonas aeruginosa is a opportunistic pathogen that can cause severe corneal infections, but it usually requires a pre-existing corneal defect or compromised immune system to invade the cornea.
**Option C:** Streptococcus pneumoniae can cause severe ocular infections, but it is not typically associated with penetration of intact corneal tissue.
**Clinical Pearl / High-Yield Fact**
Neisseria gonorrhoeae is a highly contagious and virulent bacterium that can cause severe ocular infections, including corneal ulcers and conjunctivitis. It is essential to suspect N. gonorrhoeae in patients with severe ocular symptoms, especially those with a history of recent sexual contact.
**Correct Answer:** C.