Which are the hormones seen in zona glomerulosa?
**Core Concept**
The zona glomerulosa is the outermost layer of the adrenal cortex, responsible for the production of mineralocorticoids, which play a crucial role in regulating electrolyte balance and blood pressure. The zona glomerulosa is a critical component of the adrenal gland's endocrine function.
**Why the Correct Answer is Right**
The zona glomerulosa produces two primary hormones: aldosterone and deoxycorticosterone (DOC). Aldosterone is the primary mineralocorticoid, responsible for promoting sodium retention and potassium excretion in the kidneys, which helps regulate blood pressure and electrolyte balance. DOC also has some mineralocorticoid activity, although it is less potent than aldosterone. The production of these hormones is stimulated by the renin-angiotensin-aldosterone system (RAAS), which is activated in response to low blood pressure or sodium levels.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because while the zona fasciculata produces cortisol, it is not primarily responsible for the production of mineralocorticoids like aldosterone and DOC.
* **Option B:** This option is incorrect because the zona reticularis produces androgens, such as dehydroepiandrosterone (DHEA), but not mineralocorticoids.
* **Option C:** This option is incorrect because although the adrenal medulla produces catecholamines like epinephrine, it is not responsible for the production of mineralocorticoids in the zona glomerulosa.
**Clinical Pearl / High-Yield Fact**
The zona glomerulosa is sensitive to potassium levels, and hyperkalemia can stimulate the production of aldosterone, leading to increased sodium retention and water reabsorption, which can exacerbate hypertension.
**Correct Answer: D. aldosterone and deoxycorticosterone (DOC)**