Which among the following controls is an allosteric inhibitor of TCA cyclea) Pyruvate dehydrogenaseb) Ketoglutarate dehydrogenasec) Isocitrate dehydrogenased) Malate dehydrogenase
Correct Answer: abc
Description: Pyruvate dehydrogenase; 'h' i.e., Ketoglutarate dehydrogenase & 'c' i.e., Isocitrate dehydrogenase
Allosteric modulation in TCA cycle :- Citrate synthase, a-ketoglutarate dehydrogenase, Isocitrate dehydrogenase.
Both allosteric and covalent modulation:- PDH complex.
"Citrate synthase, isocitrate dehydrogenase and a-ketoglutarate dehydrogenase are allosteric enzymes which regulate TCA cycle".
Category:
Biochemistry
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