Which amino acid&;s deamination takes place in liver?
## Core Concept
The question tests understanding of amino acid metabolism, specifically the process of deamination and its location in the body. Deamination is a critical step in amino acid catabolism, where an amino group is removed from an amino acid, resulting in the formation of ammonia and a keto acid. This process primarily occurs in the liver.
## Why the Correct Answer is Right
The correct answer, Glutamate, is a key amino acid in the process of deamination. Glutamate deamination is catalyzed by the enzyme Glutamate Dehydrogenase, which is present in the liver. This reaction converts glutamate into α-ketoglutarate and ammonia (NH3). The liver plays a crucial role in detoxifying ammonia by converting it into urea through the urea cycle. Glutamate is a major amino acid for transporting amino groups to the liver for deamination.
## Why Each Wrong Option is Incorrect
- **Option A:** While other amino acids can undergo deamination, the question specifically asks for an amino acid whose deamination takes place in the liver, and Glutamate is particularly noted for this process.
- **Option B:** and **Option C:** and **Option D:** These options are incorrect because, although they can be deaminated, they are not the primary amino acid associated with deamination in the liver.
## Clinical Pearl / High-Yield Fact
A key point to remember is that the liver is the primary site for amino acid deamination, and Glutamate is a critical amino acid in this process due to its role in the glutamate dehydrogenase reaction. This process is vital for the disposal of excess amino groups.
## Correct Answer Line
**Correct Answer: C. Glutamate**