**Core Concept**
The regulation of glycolysis involves a complex interplay of enzymes and signaling pathways. One of the key steps in regulating glycolysis is the activation of the enzyme phosphofructokinase-1 (PFK-1), which is a key kinase in the glycolytic pathway. This enzyme is a critical point of regulation in glycolysis, and its activity is influenced by a variety of factors, including hormones and energy status of the cell.

**Why the Correct Answer is Right**
The correct answer is a kinase that activates PFK-1, thereby promoting glycolysis. The activation of PFK-1 is mediated by the allosteric activator AMP-activated protein kinase (AMPK), which is a key enzyme in the regulation of energy homeostasis within the cell. AMPK is activated in response to low energy status, such as during exercise or nutrient deprivation, and it promotes glycolysis by activating PFK-1 and other glycolytic enzymes.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it is not a kinase that activates PFK-1.
* **Option B:** This option is incorrect because it is a kinase that inhibits PFK-1, rather than activating it.
* **Option D:** This option is incorrect because it is a kinase that is involved in the regulation of glycogen synthesis, rather than glycolysis.

**Clinical Pearl / High-Yield Fact**
It's worth noting that AMPK is also activated in response to metformin treatment, which is a commonly used medication for type 2 diabetes. Metformin works by activating AMPK, which promotes glycolysis and inhibits gluconeogenesis, thereby reducing blood glucose levels.

**Correct Answer:** C. AMP-activated protein kinase (AMPK)