Pharmacology When broad-spectrum antibiotics are administered with coumarin anticoagulants, the anticoagulant action may be: A Reduced because of enhanced hepatic drug metabolism B Reduced because of increased protein-binding C Increased because of reduction of vitamin 'K' sources D Increased because of decreased renal excretion of the anticoagulant 💡 Explanation When broad-spectrum antibiotics are administered with coumarin anticoagulants, the anticoagulant action may be: ✓ Correct Answer: C. Increased because of reduction of vitamin 'K' sources