**Question:** A 25-year-old female presents with a 2-year history of recurrent episodes of abdominal pain, bloating, and mild diarrhoea. She has had no weight loss, blood in stool, or fever. On examination, she has mild tenderness in the left hypochondrium. Laboratory tests show mild eosinophilia and elevated immunoglobulin E (IgE) levels. A colonoscopy is normal. What is the best treatment for this patient?

**Core Concept:** This case describes a patient with a possible diagnosis of Non-Specific Colitis (NSC), also known as Eosinophilic Colitis (EC), which is characterized by eosinophilic infiltration in the colon, causing symptoms like abdominal pain, bloating, and diarrhoea. Elevated IgE levels are common in these cases, and colonoscopy findings are typically normal.

**Why the Correct Answer is Right:** The correct answer is **D** - **Methotrexate** as it is a disease-modifying antirheumatic drug (DMARD) that can effectively suppress the immune system and reduce eosinophilic infiltration in the colon, thereby alleviating the patient's symptoms.

**Why Each Wrong Option is Incorrect:**

A. **Azathioprine:** This is a DMARD, but it is not as effective as methotrexate in reducing eosinophilic infiltration in the colon. The patient's mild eosinophilia and elevated IgE levels suggest a need for a more potent immunosuppressive therapy like methotrexate.

B. **Immunosuppressants:** While immunosuppressants are a general category of drugs that help reduce inflammation, the specific class of immunosuppressants is not mentioned in the question. Methotrexate is more specific and effective in this case.

C. **NSAIDs:** Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and inflammation but are not effective in treating eosinophilic infiltration in the colon. Methotrexate is a more appropriate choice for this patient.

D. **Vitamin D:** Vitamin D is essential for bone health but has no role in treating eosinophilic infiltration in the colon. Methotrexate is a more suitable treatment option for this patient.

**Clinical Pearl:** In cases of eosinophilic gastrointestinal disorders, a combination of clinical suspicion, laboratory data (e.g., eosinophilia, elevated IgE levels), and a normal colonoscopy should lead to the consideration of methotrexate as the treatment option. This is especially important in cases where corticosteroids are contraindicated or have failed to provide adequate relief.