**Core Concept**
Desmoid tumors, also known as aggressive fibromatoses, are rare, locally aggressive, and non-metastasizing neoplasms that arise from the musculo-aponeurotic tissues. They can occur sporadically or in association with familial adenomatous polyposis (FAP). The treatment of desmoid tumors is primarily surgical, but medical management is also essential to control tumor growth and prevent recurrence.

**Why the Correct Answer is Right**
The treatment of choice for desmoid tumors is surgical resection with wide margins, aiming to achieve complete removal of the tumor. This approach is often curative, especially for tumors with a favorable location and size. However, surgery can be challenging due to the tumor's infiltrative nature and proximity to vital structures. In cases where surgical resection is not feasible or has failed, medical management with non-steroidal anti-inflammatory drugs (NSAIDs), such as sulindac or celecoxib, can be effective in controlling tumor growth and preventing recurrence. These agents inhibit cyclooxygenase-2 (COX-2), a key enzyme involved in the production of prostaglandins, which promote tumor growth and angiogenesis.

**Why Each Wrong Option is Incorrect**
**Option A:** Chemotherapy is not the primary treatment for desmoid tumors, as these neoplasms are generally resistant to conventional chemotherapy agents.
**Option B:** Radiation therapy may be used as an adjunctive treatment for desmoid tumors, particularly in cases where surgical resection is not feasible or has failed, but it is not the first-line treatment.
**Option C:** Hormonal therapy is not typically used in the treatment of desmoid tumors, as these neoplasms are not hormone-dependent.

**Clinical Pearl / High-Yield Fact**
Desmoid tumors can exhibit a wide range of clinical behaviors, from slow-growing and asymptomatic to rapidly progressive and aggressive. A high index of suspicion is essential for early diagnosis, as delayed treatment can lead to significant morbidity and recurrence.

**Correct Answer: C. Radiation therapy may be used as an adjunctive treatment for desmoid tumors, particularly in cases where surgical resection is not feasible or has failed, but it is not the first-line treatment.