Pathology What is the pathogenetic mechanism of HPV in causing cervical carcinoma? A Down regulation of 16INK4 protein B Degradation of cyclin D1 C Genomic instability of E6 and E7 D Up regulation of BCL2 💡 Explanation What is the pathogenetic mechanism of HPV in causing cervical carcinoma? ✓ Correct Answer: C. Genomic instability of E6 and E7