Radiology What is the most impoant lesion produced in chromosomal DNA by exposure to ionizing radiation? A A break on one DNA strand ('single-strand break') B Well-separated breaks on both DNA strands C Breaks on both DNA strands which are opposite each other or separated by only a few bases ('double-strand break') D Multiple breaks on the same DNA strand 💡 Explanation What is the most impoant lesion produced in chromosomal DNA by exposure to ionizing radiation? ✓ Correct Answer: C. Breaks on both DNA strands which are opposite each other or separated by only a few bases ('double-strand break')