What is the mode of action of Sodium C romoglycate?
**Core Concept**
Sodium Cromoglycate is a mast cell stabilizer, which is used in the management of allergic reactions, particularly in conditions such as allergic rhinitis, asthma, and atopic dermatitis. It works by stabilizing the mast cell membrane, thereby preventing the release of histamine and other mediators that contribute to allergic inflammation.
**Why the Correct Answer is Right**
Sodium Cromoglycate inhibits the release of histamine and other chemical mediators from mast cells by stabilizing their membranes. This is achieved through the inhibition of calcium ion influx into the mast cell, which is essential for the activation of the mast cell degranulation process. By preventing the release of histamine, Sodium Cromoglycate reduces the symptoms associated with allergic reactions, such as itching, sneezing, and bronchospasm.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Sodium Cromoglycate does not act as an antihistamine, which is a class of medications that block the action of histamine at its receptor sites.
**Option B:** This option is incorrect because Sodium Cromoglycate is not a corticosteroid, which is a class of medications that reduce inflammation by suppressing the immune system.
**Option C:** This option is incorrect because Sodium Cromoglycate does not act as a bronchodilator, which is a class of medications that relax the muscles in the airways to improve breathing.
**Clinical Pearl / High-Yield Fact**
Sodium Cromoglycate is often used in combination with other medications, such as inhaled corticosteroids, to control symptoms of asthma and allergic rhinitis. It is particularly useful in patients who are sensitive to antihistamines or corticosteroids.
**Correct Answer: C. It inhibits the release of histamine and other chemical mediators from mast cells.**