Anaesthesia What is the mode of action of local anesthetics? A Prevents Na+ channel activation and the Na+ influx associated with membrane depolarization. B Change the voltage gated Na+ channel from conducting to non conducting C Destroys the Na+ channel D Close the Na+ channel 💡 Explanation What is the mode of action of local anesthetics? ✓ Correct Answer: A. Prevents Na+ channel activation and the Na+ influx associated with membrane depolarization.