## **Core Concept**
Tuberous sclerosis complex (TSC) is a genetic disorder characterized by the growth of non-cancerous tumors in multiple organs, including the brain, kidneys, heart, lungs, and skin. The condition is caused by mutations in the TSC1 or TSC2 genes, leading to the activation of the mTOR pathway. Clinical manifestations vary widely among affected individuals.

## **Why the Correct Answer is Right**
The correct answer, , is associated with a condition or feature not typically observed in tuberous sclerosis. To accurately determine this, let's evaluate each option in the context of TSC.

## **Why Each Wrong Option is Incorrect**
- **Option A:** is a feature commonly seen in tuberous sclerosis.
- **Option B:** is also commonly associated with TSC.
- **Option C:** represents another characteristic finding in patients with tuberous sclerosis.

## **Clinical Pearl / High-Yield Fact**
A key clinical pearl for tuberous sclerosis is the classic triad of **seizures**, **mental retardation**, and **adenoma sebaceum** (facial angiofibromas), though not all patients exhibit all three. Early diagnosis and management can significantly impact patient outcomes.

## **Correct Answer:** .