What constitutes the driving force for transpo of proteins into and out of the nucleus?
Correct Answer: GTP hydrolysis within the cytosol
Description: No ATP is involved at any point in nuclear transpo. The driving force for the transpo comes indirectly from a gradient created by GTP hydrolysis. The key controlling factor is the allosteric GTPase, Ran. Ran is only able to hydrolyze GTP to GDP in the cytosol because this process must be activated by a GTPase-activating protein (GAP) that is only present in the cytosol. Reference: Harper; 30th edition
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now