Warfarin therapy is prolonged by all except:
Correct Answer: Rifampicin
Description: Barbiturates (but not benzodiazepines), carbamazepine, rifampicin and griseofulvin induce the metabolism of warfarin.The dose of anticoagulant determined during therapy with these drugs would be higher: if the same is continued after withdrawing the inducer- marked hypoprothrombinemia can occur causing fatal bleeding.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 670
Category:
Pharmacology
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