Von Wiliebrand disease is associated with –
Correct Answer: | PTT; Normal PT; | BT; | CT
Description: Ans. is 'd' i.e., |PTT; Normal PT; |BT; |CT LABORATORY DIAGNOSIS OF VON WILLEBRAND'S DISEASE.Screening testsVon Vilebrand disease||Deficiency ofVonvilebrand factordefect in factor VIIIc(VWf carries VIIIc)||Leads to plateletdysfunctionLeads to defect inintrinsic coagulation pathway||o Increased bleeding timeQo Increased PTTQo Normal PTQo Increased clotting timeQ Laboratory findings in Von wilebrand diseaseo Tourniquet test (Hess test)- Is positive because of defective platelet adhesionso Bleeding time- Prolonged because of platelet function defecto APTT- Prolonged because of secondarily reduced VIIIc activityo VWF assay- | levelso Ristocetin induced aggregation is defective- It Is diagnostic of vWD. This is insensitive to mild deficiency of vWF. However in platelet type vWD - Ristocetin induced platelet aggregation is increasedo vWF immunoassay- Levels of VWF antigen (VWF: Ag) axe assayed by EUSAor automated assays and are reduced in type vWD while in type 2 vWD, the vWF: Ag levels may be normal indicating that just measuring VWF: Ag is not enough for diagnosing vWDo Muitimeric analysis of vWF o Genetic studies of specific CDNA regions
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now