Vitamin K in its coenzyme form is regenerated by which enzyme?
Correct Answer: Epoxide reductase
Description: Vitamin K - Vitamin K hydroquinone is oxidized to the epoxide Epoxide activates a glutamate residue in the protein substrate to a carbanion, which reacts nonenzymically with carbon dioxide to form g-carboxyglutamate. Vitamin K epoxide is reduced to the quinone by an epoxide reductase, and the quinone is reduced to the active hydroquinone by Vitamin K reductase. Dicumarol & warfarin inhibits the enzyme (reductase) that conves epoxide to active Vitamin K (hydroquinone).
Category:
Biochemistry
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