**Core Concept**
Vitamin K dependent clotting factors are a group of coagulation proteins that require the presence of vitamin K for their synthesis and activation. These factors are essential for the coagulation cascade, which ultimately leads to the formation of a blood clot to prevent excessive bleeding.

**Why the Correct Answer is Right**
Vitamin K dependent clotting factors include Factors II (prothrombin), VII, IX, and X. These factors are synthesized in the liver and require vitamin K for their gamma-carboxylation, which is necessary for their binding to phospholipid surfaces. This process enables these factors to participate in the coagulation cascade and form a stable blood clot. The gamma-carboxylation reaction involves the vitamin K-dependent enzyme complex, which includes vitamin K epoxide reductase, vitamin K-dependent carboxylase, and other associated proteins.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not specified, but typically, Factor VIII is not a vitamin K dependent clotting factor; it is a labile factor that requires calcium ions for its activity.
* **Option B:** This option is not specified, but typically, Factor V is a labile factor that is not dependent on vitamin K for its activity.
* **Option C:** This option is not specified, but typically, Factor XI is a plasma serine protease that is not dependent on vitamin K for its activity.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that vitamin K deficiency can lead to a coagulopathy characterized by bleeding, and that warfarin, a vitamin K antagonist, is commonly used as an anticoagulant to prevent thrombosis.

**Correct Answer:**
D. Factors II, VII, IX, and X