Vigabatrin acts through –

A. decreasing GABA uptake at synaptic cleft

B. Increasing GABA uptake at synaptic cleft

C. GABA transaminase inhibitor

D. GABA transacetylase inhibitor

Correct Answer: GABA transaminase inhibitor

Description: Ans. is 'c' i.e., GABA transaminase inhibitor Vigabatrin (g vinyl GABA)* It is a newer anti - convulsant which is an inhibitor of enzyme GABA transaminase; it thus increases GABA concentration at synapse.* It is mainly used in patients with refractory epilepsy visual field defects and behavioural changes restricts its use.

Category: Pharmacology

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