**Core Concept**
ANCA (Anti-Neutrophil Cytoplasmic Antibodies) positive vasculitis refers to a group of autoimmune disorders characterized by the presence of ANCA and inflammation of blood vessels. These conditions are often associated with the presence of specific autoantibodies targeting certain components of neutrophils.

**Why the Correct Answer is Right**
Goodpasture's syndrome is a distinct autoimmune disease that primarily targets the glomerular basement membrane and pulmonary alveolar basement membrane, leading to glomerulonephritis and pulmonary hemorrhage. Unlike ANCA-associated vasculitides, Goodpasture's syndrome is characterized by the presence of anti-GBM (glomerular basement membrane) antibodies, not ANCA. This distinction is crucial in diagnosing and managing these conditions.

**Why Each Wrong Option is Incorrect**
**Option A:** Wegener's granulomatosis (now known as Granulomatosis with Polyangiitis) is a classic example of an ANCA-associated vasculitis, characterized by the presence of c-ANCA (cytoplasmic ANCA) and granulomatous inflammation.

**Option B:** Churg-Strauss syndrome (now known as Eosinophilic Granulomatosis with Polyangiitis) is another ANCA-associated vasculitis, typically associated with the presence of p-ANCA (perinuclear ANCA) and significant eosinophilia.

**Option C:** Microscopic Polyangiitis (MPA) is a small-vessel vasculitis that is often associated with the presence of p-ANCA, making it another member of the ANCA-associated vasculitis group.

**Clinical Pearl / High-Yield Fact**
When evaluating patients with suspected vasculitis, it is essential to consider the type of ANCA present (c-ANCA vs. p-ANCA) and the clinical features, as this can guide targeted therapy and improve outcomes.

**Correct Answer Line**
✓ Correct Answer: D. Good pasture's syndrome