Varicella zoster virus belongs to which family of DNA viruses –
**Core Concept**
Varicella zoster virus (VZV) is a double-stranded DNA virus that causes chickenpox and shingles. It is a member of the Herpesviridae family, which comprises a large group of DNA viruses that can cause a wide range of diseases in humans.
**Why the Correct Answer is Right**
The Herpesviridae family is characterized by its large genome size, ranging from 125 to 240 kilobase pairs, and its ability to establish lifelong latent infections in humans. VZV, like other herpesviruses, has a complex life cycle that involves replication in the nucleus of infected cells, followed by reactivation from latency. This unique life cycle is mediated by the viral enzyme thymidine kinase, which plays a crucial role in the replication and reactivation of VZV.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the Poxviridae family consists of large, complex DNA viruses that cause diseases such as smallpox and cowpox.
**Option B:** This option is incorrect because the Adenoviridae family consists of medium-sized DNA viruses that cause a range of diseases, including common cold and gastroenteritis.
**Option C:** This option is incorrect because the Papovaviridae family is now considered obsolete and has been replaced by the Papillomaviridae and Polyomaviridae families, which consist of small DNA viruses that cause diseases such as human papillomavirus and polyomavirus.
**Clinical Pearl / High-Yield Fact**
The Herpesviridae family is known for its ability to cause lifelong latent infections, which can be reactivated by various stimuli, including stress, immunosuppression, and aging. This unique feature of herpesviruses makes them a significant public health concern, particularly in immunocompromised individuals.
**Correct Answer:** C. Herpesviridae.