Tzank smear in varicella-zoster shows ?
**Core Concept**
The Tzank smear is a diagnostic tool used to identify viral infections, particularly herpesviruses, by examining the cytopathic effects on epithelial cells. It is a rapid diagnostic method that helps in differentiating between various viral infections.
**Why the Correct Answer is Right**
In varicella-zoster infection, the Tzank smear shows multinucleated giant cells, also known as "ground glass" cells, which are formed due to the fusion of adjacent epithelial cells. This fusion occurs as a result of the viral infection, leading to the formation of multinucleated giant cells. The presence of these cells is a characteristic feature of varicella-zoster infection and helps in its diagnosis. The multinucleated giant cells are formed due to the action of the viral envelope glycoproteins, which facilitate the fusion of adjacent cells.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is likely referring to the presence of inclusion bodies, which are characteristic of other viral infections such as herpes simplex virus. However, the presence of inclusion bodies is not a specific feature of varicella-zoster infection.
**Option B:** This option is incorrect as the Tzank smear does not typically show the presence of bacteria in varicella-zoster infection.
**Option C:** This option is likely referring to the presence of neutrophils or other inflammatory cells, which are not characteristic of varicella-zoster infection.
**Clinical Pearl / High-Yield Fact**
The Tzank smear is a rapid and useful diagnostic tool for identifying viral infections, particularly herpesviruses. It is essential to remember that the presence of multinucleated giant cells is a characteristic feature of varicella-zoster infection, and it can aid in differentiating it from other viral infections.
**Correct Answer:** C. Multinucleated giant cells.