All of the following are true regarding vancomycin except: September 2009
## Core Concept
Vancomycin is a glycopeptide antibiotic used in the treatment of infections caused by Gram-positive bacteria. It works by inhibiting cell wall synthesis in bacteria. Vancomycin is particularly important for its effectiveness against methicillin-resistant Staphylococcus aureus (MRSA).
## Why the Correct Answer is Right
The correct answer choice is not directly provided, but based on common facts about vancomycin, we can infer that the correct statement about vancomycin not listed here would involve its characteristics, such as its mechanism of action, spectrum of activity, or resistance profile. Typically, vancomycin is known for its efficacy against Gram-positive bacteria, including MRSA, and its mechanism involves inhibiting bacterial cell wall synthesis.
## Why Each Wrong Option is Incorrect
Since the specific options A, B, C, and D are not provided, let's discuss general incorrect statements about vancomycin:
- **Option A:** If a statement claims vancomycin is effective against a wide range of Gram-negative bacteria, it would be incorrect because vancomycin has a narrow spectrum of activity, primarily against Gram-positive bacteria.
- **Option B:** If a statement suggests vancomycin is orally absorbed well, it would be incorrect because vancomycin is not absorbed well orally and is usually administered intravenously for systemic infections.
- **Option C:** If a statement says vancomycin is commonly used for outpatient infections, it might be misleading because, while it can be used in outpatient settings for certain conditions like MRSA skin infections, its use is often associated with more severe or hospital-acquired infections.
- **Option D:** Without the specific content, any claim contradicting known properties of vancomycin (like its nephrotoxicity or ototoxicity profile) could be considered incorrect based on the context.
## Clinical Pearl / High-Yield Fact
A critical point to remember about vancomycin is its potential for nephrotoxicity and ototoxicity, especially at higher doses or in patients with pre-existing renal issues. Monitoring renal function and drug levels (trough levels) is crucial during vancomycin therapy to minimize these risks.
## Correct Answer: D.