**Question:** Vaccine which can be stored at-10°C temperature

**Core Concept:** Different vaccines have varying requirements for storage and transportation due to their composition and stability. Some vaccines can be stored at lower temperatures, making their distribution and administration easier in less developed regions.

**Why the Correct Answer is Right:** The correct answer is **D) DPT (Diphtheria, Pertussis, and Tetanus)**. DPT is a vaccine that contains live attenuated bacteria or viruses and requires a cold chain to maintain its potency. At-10°C is a suitable temperature for storage, as it falls within the recommended temperature range of -20°C to +2°C.

**Why Each Wrong Option is Incorrect:**

A) **Poliovirus vaccine:** Polio vaccine requires a cold chain but is more sensitive to temperature fluctuations. Storage at -10°C may cause its potency to diminish.

B) **Measles vaccine:** Measles vaccine also requires a cold chain but is more sensitive to temperature fluctuations. Storage at -10°C may cause its potency to diminish.

C) **BCG (Bacille Calmette-Guérin) vaccine:** BCG is a live attenuated mycobacterium vaccine that can tolerate some temperature fluctuations. However, storing it at -10°C might still be too cold and negatively impact its potency.

**Clinical Pearl:** It is essential to maintain the proper cold chain for vaccines to ensure their efficacy in preventing diseases. Inadequate storage can lead to reduced immunogenicity and decreased protection against the targeted infections. This emphasizes the importance of proper vaccine distribution and management systems in public health programs.