Vaccine contrainidicated in pregnancy is
**Core Concept**
Live attenuated vaccines are typically contraindicated in pregnancy due to the theoretical risk of transmission of the attenuated virus to the fetus. This is particularly concerning for vaccines like the MMR (measles, mumps, and rubella) vaccine, which contains live, attenuated strains of the measles, mumps, and rubella viruses.
**Why the Correct Answer is Right**
The MMR vaccine contains live, attenuated viruses, which can potentially cause infection in a pregnant woman. This could lead to complications for the fetus, including congenital rubella syndrome, which can cause birth defects and other serious health problems. Live attenuated vaccines are generally avoided in pregnancy, as the risk of transmission to the fetus outweighs any potential benefits.
**Why Each Wrong Option is Incorrect**
* **Option A:** Inactivated vaccines, such as the flu vaccine, are generally safe for use in pregnancy and are not contraindicated.
* **Option B:** The HPV vaccine is a subunit vaccine, which means it does not contain live or attenuated viruses, making it safe for use in pregnancy.
* **Option C:** The Tdap vaccine is a combination vaccine that includes inactivated pertussis toxin, making it safe for use in pregnancy.
**Clinical Pearl / High-Yield Fact**
Remember that live attenuated vaccines are generally contraindicated in pregnancy, while inactivated and subunit vaccines are generally safe.
**Correct Answer: C. The MMR vaccine.**