During pregnancy, vaccination can be fiven against all these diseases expect-
**Core Concept**
Live vaccines are contraindicated in pregnancy due to the theoretical risk of transmission of the live, attenuated virus to the fetus.
**Why the Correct Answer is Right**
During pregnancy, the immune system undergoes various changes to accommodate the developing fetus. Live vaccines, which contain weakened forms of the pathogen, pose a risk of transmitting the virus to the fetus. This risk is particularly concerning for diseases like rubella, which can cause congenital rubella syndrome if contracted during pregnancy. The Centers for Disease Control and Prevention (CDC) and other health organizations recommend avoiding live vaccines during pregnancy, opting instead for inactivated or toxoid vaccines, which are safer.
**Why Each Wrong Option is Incorrect**
**Option A:** Inactivated influenza vaccine (TIV) is recommended during pregnancy to protect against seasonal flu.
**Option B:** Tdap vaccine is recommended during pregnancy to protect against pertussis (whooping cough), a highly contagious respiratory illness.
**Option C:** Inactivated Hepatitis A vaccine can be given to pregnant women who are at high risk of exposure, such as travelers to endemic areas or individuals with underlying liver disease.
**Clinical Pearl / High-Yield Fact**
Pregnant women should avoid live vaccines, including MMR, Varicella, and Influenza (LAIV), but can receive inactivated or toxoid vaccines, such as TIV, Tdap, and Hepatitis A.
**Correct Answer:** C. Inactivated Hepatitis A vaccine can be given to pregnant women who are at high risk of exposure, such as travelers to endemic areas or individuals with underlying liver disease.