UV light causes mutation in cells by
**Core Concept**
UV light exposure leads to the formation of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts, causing DNA damage and mutations. This occurs due to the absorption of UV radiation by DNA, resulting in the formation of these DNA adducts.
**Why the Correct Answer is Right**
The formation of CPDs and 6-4 photoproducts is a direct result of the absorption of UV radiation by DNA. The energy from UV light causes adjacent pyrimidine bases (cytosine and thymine) to form covalent bonds, leading to the formation of these DNA adducts. This damage can cause mutations if not properly repaired by DNA repair mechanisms. The nucleotide excision repair (NER) pathway is responsible for repairing UV-induced DNA damage, including CPDs and 6-4 photoproducts.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, please provide the correct options for the question.
**Option B:** This option is not provided, please provide the correct options for the question.
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**Clinical Pearl / High-Yield Fact**
The UV-induced formation of CPDs and 6-4 photoproducts is a major contributing factor to the development of skin cancers, including melanoma. The use of sunscreen and protective clothing can help prevent UV-induced DNA damage and reduce the risk of skin cancer.
**Correct Answer:** Not provided, please provide the correct options for the question.