Urine turns dark on standing in: (Repeat)
Correct Answer: Alkaptonuria
Description: Ans: A (Alkaptonuria) Ref: Harrison's Principles of Internal Medicine 18th edition & Harper's illustrated Biochemistry, 28th edition. Chapter 29, pp 254)Explanation:AlkaptonuriaDue to deficiency in homagentisic acid oxidaseResults in the accumulation of homogentisic acidThe illness has three characteristic symptoms;Homogentisicaciduria (the patient's urine contains elevated levels of homogentisic acid, which is oxidized to a dark pigment on standing,Large joint arthritisBlack ochronotic pigmentation of cartilage and collagenous tissue tOochronsis)Diets low in protein--especially in phenylalanine and tyrosine--help reduce the levels of homogentisic acid, and decrease the amount of pigment deposited in body tissues.Although alkaptonuria is not life-threatening, the associated arthritis may be severely crippling.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now