26 yr lady with delayed cycles presents to the infeility clinic. After diagnosing her to be a case anovulation of ‘Normogonadotropic Hypogonadism’ type she was put on human menopausal gonadotropin (HMG) for ovulation induction from the second day of her menstrual period. She was ‘Triggered’ for follicular rupture with Human chorionic gonadotropin (hCG) and on the 19th day of this cycle she developed dyspnoea, reduced urine output, abdominal bloating and pain. What condition is this patient likely suffering from?
26 yr lady with delayed cycles presents to the infeility clinic. After diagnosing her to be a case anovulation of ‘Normogonadotropic Hypogonadism’ type she was put on human menopausal gonadotropin (HMG) for ovulation induction from the second day of her menstrual period. She was ‘Triggered’ for follicular rupture with Human chorionic gonadotropin (hCG) and on the 19th day of this cycle she developed dyspnoea, reduced urine output, abdominal bloating and pain. What condition is this patient likely suffering from?
π‘ Explanation
**Core Concept**
The patient is suffering from ovarian hyperstimulation syndrome (OHSS), a complication of ovulation induction and assisted reproductive technologies. OHSS is characterized by an exaggerated response to hCG, leading to increased ovarian size, ascites, and potentially life-threatening complications.
**Why the Correct Answer is Right**
The patient was treated with HMG for normogonadotropic hypogonadism, which stimulates follicular growth. The addition of hCG triggers ovulation and can exacerbate OHSS. The symptoms developed by the patient, including dyspnea, reduced urine output, and abdominal bloating and pain, are consistent with fluid overload and ascites. The pathophysiology of OHSS involves the increased production of vascular endothelial growth factor (VEGF), which leads to increased vascular permeability and fluid leakage into the peritoneal cavity.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because while pelvic inflammatory disease (PID) can cause abdominal pain and dyspnea, it does not typically present with ascites or reduced urine output.
**Option B:** This option is incorrect because acute kidney injury (AKI) can cause reduced urine output, but it does not explain the patient's abdominal bloating and pain.
**Option C:** This option is incorrect because ectopic pregnancy is a potential complication of assisted reproductive technologies, but it does not typically present with ascites or the constellation of symptoms described.
**Clinical Pearl / High-Yield Fact**
OHSS is more common in patients with polycystic ovary syndrome (PCOS) and those who have undergone ovarian stimulation with HMG or recombinant FSH.
**Correct Answer: D. Ovarian Hyperstimulation Syndrome (OHSS)**
β Correct Answer: B. Ovarian hyperstimulation syndrome
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