Uricosuric drug among these is :
**Core Concept**
Uricosuric drugs are a class of medications that increase the excretion of uric acid in the urine, thereby reducing serum uric acid levels. This is particularly useful in the treatment of conditions such as gout, where uric acid crystals deposit in the joints, causing inflammation and pain.
**Why the Correct Answer is Right**
The correct answer is **Probenecid**. Probenecid works by inhibiting the reabsorption of uric acid in the proximal tubules of the kidneys, thereby increasing its excretion in the urine. This is achieved through the inhibition of the urate transporter (URAT1) in the kidneys, which is responsible for the reabsorption of uric acid.
**Why Each Wrong Option is Incorrect**
* **Option A:** **Aspirin** is not a uricosuric drug; it can actually increase uric acid levels in some individuals by inhibiting the enzyme xanthine oxidase, which is involved in the production of uric acid.
* **Option B:** **Allopurinol** is a xanthine oxidase inhibitor that decreases uric acid production in the body, but it is not a uricosuric drug.
* **Option C:** **Benzbromarone** is a uricosuric drug that works by inhibiting the reabsorption of uric acid in the kidneys, but it is not the correct answer in this case.
**Clinical Pearl / High-Yield Fact**
When prescribing uricosuric drugs, it's essential to note that they can increase the risk of kidney stones, particularly uric acid stones, due to the increased excretion of uric acid in the urine.
**Correct Answer: B. Allopurinol**