Uncoupler in ETC
Correct Answer: 2, 4-dinitrophenol
Description: Dinitrophenol (DNP) a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146
Category:
Biochemistry
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