Pathology Which of the following is earliest sign of ulcerative colitis on double contrast barium enema (DCBE) study? A Fine Mucosal granularity B Loss of haustrations C 'Collar-button' ulcers D Lead pipe colon 💡 Explanation Which of the following is earliest sign of ulcerative colitis on double contrast barium enema (DCBE) study? ✓ Correct Answer: A. Fine Mucosal granularity