Type 2 hypercholesterolemia occurs due to
Correct Answer: Absence of LDL receptors on cells
Description: Type II A(Primary familial hypercholesterolemia) There is elevation of LDL. Patients seldom survive the second decade of life due to ischemic hea disease (Table 25.4). The cause is LDL receptor defect. Receptor deficiency in liver and peripheral tissues will result in the elevation of LDL levels in plasma, leading to hypercholesterolemia. The LDL receptor defect may be due to the following reasons:LDL receptor deficiency.Defective binding of B-100 to the receptor. A substitution of glutamine for arginine at 3500thamino acid results in poor binding to LDL receptors. This defect is known as B-3500 or familial defective apo-B.Receptor-LDL complex is not internalised. Secondary type II hyperlipoproteinemia is seen in hypothyroidism, diabetes mellitus, nephrotic syndrome and cholestasis
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now