**Core Concept:** Turner's syndrome is a genetic disorder characterized by the absence of one X chromosome in females, resulting in a partial or complete monosomy X. This leads to various clinical manifestations, including growth retardation, gonadal dysgenesis, and distinct physical features.

**Why the Correct Answer is Right:** Turner's syndrome most commonly affects females due to the presence of X chromosomes. In this case, the condition results from the absence of one X chromosome (monosomy X), which leads to developmental abnormalities and characteristic features.

**Why Each Wrong Option is Incorrect:**
A. This option refers to a different condition, Klinefelter syndrome, which occurs in males with an extra X chromosome (47,XXY). In Turner's syndrome, the problem lies in the absence of an X chromosome, not an extra one.
B. Though Turner's syndrome does impact females, the correct answer refers to the presence of X chromosomes, not the absence of Y chromosomes, which are present in males.
C. Turner's syndrome affects females due to a lack of one X chromosome, not the presence of Y chromosomes, which are absent in females.
D. This option is incorrect as Turner's syndrome affects females, not males.

**Clinical Pearl:** Turner's syndrome is a crucial concept in understanding reproductive and developmental abnormalities in females. It is essential for clinicians to know how to diagnose and manage the condition, which may lead to infertility, cardiovascular issues, and other complications.

**Correct Answer:** C. Turner's syndrome most commonly affects females due to the presence of X chromosomes, which are absent in individuals with Turner's syndrome.