Which of the following tumours present with proptosis-
**Core Concept**
Neuroblastoma is a type of pediatric cancer that arises from the neuroblasts of the sympathetic nervous system, often presenting with proptosis due to orbital involvement. Proptosis, or bulging of the eye, is a clinical manifestation of orbital tumor extension.
**Why the Correct Answer is Right**
Neuroblastoma is a highly vascular tumor that can invade the orbit and cause proptosis. The tumor's growth in the orbit pushes the globe forward, resulting in a bulging appearance. This is often accompanied by other symptoms such as eyelid swelling, eye movement abnormalities, and vision disturbances. In children, neuroblastoma is the most common extracranial solid tumor, and orbital involvement is a common presenting feature.
**Why Each Wrong Option is Incorrect**
**Option B:** Nephroblastoma, also known as Wilms tumor, is a pediatric kidney cancer that primarily presents with abdominal symptoms such as a palpable mass and hematuria. Orbital involvement is rare in nephroblastoma.
**Option C:** Germ cell tumors can occur in the orbit, but they are less common and typically present with different symptoms such as vision disturbances and pain.
**Option D:** Medulloblastoma is a type of brain tumor that primarily affects the cerebellum and presents with symptoms such as ataxia, nystagmus, and hydrocephalus. Orbital proptosis is not a characteristic feature of medulloblastoma.
**Clinical Pearl / High-Yield Fact**
In children, neuroblastoma is the most common cause of proptosis, and orbital involvement is often associated with advanced disease and poor prognosis. A high index of suspicion is necessary for early diagnosis and treatment.
β Correct Answer: A. Neuroblastoma