Tumor marker of ca ovary for follow up
**Core Concept**
Ca ovarian follow up requires regular assessment of tumor markers to detect recurrence. **CA-125** is the most commonly used tumor marker for epithelial ovarian cancer, particularly for monitoring disease progression and response to treatment.
**Why the Correct Answer is Right**
CA-125 is a mucin-like glycoprotein produced by the epithelial cells of the ovary and other tissues. Elevated levels of CA-125 are associated with ovarian cancer, particularly serous epithelial ovarian cancer. Monitoring CA-125 levels helps in assessing the effectiveness of treatment and detecting recurrence. However, it's essential to note that CA-125 can also be elevated in benign conditions such as endometriosis, pelvic inflammatory disease, and during menstruation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because **AFP (Alpha-fetoprotein)** is primarily used as a tumor marker for germ cell tumors like yolk sac tumor and hepatocellular carcinoma.
**Option B:** This option is incorrect because **CEA (Carcinoembryonic antigen)** is a tumor marker for colorectal cancer, breast cancer, and other malignancies, but not specifically for ovarian cancer.
**Option C:** This option is incorrect because **PSA (Prostate-specific antigen)** is a tumor marker for prostate cancer and has no association with ovarian cancer.
**Clinical Pearl / High-Yield Fact**
CA-125 levels can be elevated in various conditions, making it essential to interpret results in the context of clinical presentation and imaging findings. A rising CA-125 level in a patient with a history of ovarian cancer suggests recurrence, while a stable or decreasing level indicates a favorable response to treatment.
**Correct Answer: C. CA-125**