**Core Concept**
The question is testing the knowledge of tuberculosis detection methods, specifically in mass screening. Mass screening is a public health strategy aimed at detecting diseases in a large population. In the context of tuberculosis, mass screening is crucial for early detection and treatment to prevent the spread of the disease.

**Why the Correct Answer is Right**
The most effective method of choice for tuberculosis detection in mass screening is the **Mantoux tuberculin skin test (TST)**. The TST involves injecting a small amount of purified protein derivative (PPD) of Mycobacterium tuberculosis into the skin, and the reaction is measured after 48-72 hours. A positive reaction indicates that the individual has been infected with M. tuberculosis. The TST is widely used in mass screening due to its simplicity, low cost, and ability to detect latent tuberculosis infection.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a standard method for tuberculosis detection in mass screening. While it may be used in certain contexts, it is not the preferred choice for mass screening.
**Option B:** This option is incorrect because it is not a specific method for detecting tuberculosis. It is a general term that can refer to various screening tests, but it is not the method of choice for tuberculosis detection.
**Option C:** This option is incorrect because it is not a widely used method for tuberculosis detection in mass screening. While it may be used in certain clinical settings, it is not the preferred choice for mass screening due to its complexity and cost.

**Clinical Pearl / High-Yield Fact**
The Mantoux TST has a few limitations, including cross-reactivity with other mycobacteria and false-positive results in individuals with certain medical conditions. However, it remains the most widely used method for tuberculosis detection in mass screening due to its simplicity and low cost.

**Correct Answer:** **C**.